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Independent Human Study Shows Mannatech's Ambrotose AO® Product to be Beneficial Antioxidant Supplement

(COPPELL, Texas) May 25, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of an independent human clinical study that demonstrated intake of its proprietary Ambrotose AO® capsules raised antioxidant protection in serum oxygen radical absorbance capacity (ORAC) in healthy adults, further validating a previous human study.*

The effect on serum ORAC, a method of measuring antioxidant capacities, was very similar between the two studies. The 2010 five-week study by Dr. Stephen P. Myers of 21 healthy adults by physicians and scientists from Australia and New Zealand showed that four capsules per day of Ambrotose AO dietary supplement was safe and raised ORAC by 36.6 percent.1

The 2003 pilot study of 12 healthy adults by Dr. Stephen Boyd, Mannatech’s Senior Director, Medical Affairs, Mannatech scientists and an independent statistician showed that two capsules per day of Ambrotose AO capsules increased ORAC by 37.4 percent.2

“We are proud to have two human clinical studies that consistently show our Ambrotose AO product improves antioxidant status of human blood. These results demonstrate antioxidants in Ambrotose AO capsules provide the best antioxidant protection available today,” said Mannatech’s Co-CEO and Chief Science Officer Robert A. Sinnott, MNS, Ph.D. “Antioxidants help reduce the amount of free radicals and oxidative stress that can damage or even kill cells. In addition to providing antioxidant support, many of the nutrients in Ambrotose AO capsules have been shown to promote a healthy immune system.”* †

Mannatech’s Ambrotose AO capsules appear to be the most promising antioxidant supplement investigated to date. Ambrotose AO capsules increased human serum ORAC levels more than a number of well-known antioxidant foods and other commercial products: in food studies, increases in serum ORAC have been documented following ingestion of strawberries (14.4 percent increase) or spinach (28.5 percent increase)3, buckwheat honey (7 percent increase)4 or Concord grape juice (8 percent increase)5. In a placebo-controlled trial of healthy adults, a single 100g dose of wild blueberry powder significantly increased serum ORAC by up to 16 percent6 and a single 1.25g dose of vitamin C raised serum ORAC by 23 percent3. Additional studies of supplements designed to exert antioxidant benefits showed no effect on serum ORAC: a fruit-based antioxidant drink (MonaVie Active®)7,8.

Professor Stephen Myers, Ph.D., BMed, ND is Director of the Australian Centre for Complementary Medicine Education and Research (ACCMER), a unique joint venture of the University of Queensland and Southern Cross University (SCU) and the NatMed-Research Unit, Research Cluster for Health and Wellbeing (NRU-RCHW), SCU, Lismore, AU. The study’s findings were published in the peer‐reviewed BMC Complementary and Alternative Medicine.

Currently, Mannatech holds more than 45 patents in 30 countries for the technology related to Ambrotose complex. In addition, many of Mannatech’s products are based on Real Food TechnologySM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

For technical information about Mannatech’s products and scientific research publications, visit

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

† Mannatech, Incorporated funded both studies and donated the Ambrotose products used in each study.

1 Myers SP, Stevenson L, Cheras PA, et al. (2010) A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC Comp Alt Med 10, doi: 10.1186/1472-6882-10-16.

2 Boyd S, Gary K, Koepke, et al. (2003) An open-label pilot study of the antioxidant effect in healthy people of Ambrotose AO. GlycoScience & Nutrition 4:1-6.

3 Cao G, Russell RM, Lischner N, Prior RL: Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr 1998, 128: 2383-2390.

4 Gheldof N, Wang XH, Engeseth NJ: Buckwheat honey increases serum antioxidant capacity in humans. J Agric Food Chem 2003, 51: 1500-1505.

5 O’Byrne DJ, Devaraj S, Grundy SM, Jialal I: Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr 2002, 76: 1367-1374.

6 Kay CD, Holub BJ: The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr 2002, 88: 389-398.

7 Jensen GS, Wu X, Patterson KM, Barnes J, Carter SG, Scherwitz L et al.: In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. J Agric Food Chem 2008, 56: 8326-8333.

8 MonaVie Active is a registered trademark of MONAVIE, LLC.