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Randomized, Double-Blind, Controlled Human Study Finds Mannatech’s Ambrotose® Complex Improves Cognition and Well-Being*

(COPPELL, Texas) January 8, 2010Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of a randomized, double-blind, placebo-controlled study that shows healthy middle-aged adults who took one teaspoon of Ambrotose® complex1 twice daily performed significantly better on memory tasks and were overall more positive in their mood.2 *

Drs. Talitha Best and Eva Kemps of Flinders University in Adelaide, Australia, and Dr. Janet Bryan of the University of South Australia in Adelaide, Australia, published their findings of the 12-week study in the January 2010 issue of Developmental Neuropsychology, a peer-reviewed scientific journal.

“This rigorous double-blind, placebo-controlled study confirms important biological effects of Mannatech's flagship and proprietary product, Ambrotose complex,” said Dr. Robert A. Sinnott, MNS, PhD, co-chief executive officer and chief science officer of Mannatech. “The significantly better performance on memory tasks and positive effects on mood experienced by the study participants who consumed Ambrotose complex is congruent with beneficial effects on brain functions.”*

The abstract of the study states that: “Before and after this supplementation period, participants completed alternate forms of standardized tests of cognition and self-report measures of well-being. Significant beneficial and longer-term effects of saccharide supplementation were found for memory performance and indicators of well-being. The potential for these nutrients to optimize cognitive function and well-being in older adults warrants on-going investigation.”2 *

“Right now, commercial development of compounds to enhance cognitive functioning is one of the hottest areas of biomedical research,” Sinnott continued. “While most research focuses around synthetic compounds, Mannatech's Ambrotose complex is comprised of ingredients that are isolated and purified from renewable natural sources, primarily plants. Mannatech has pioneered the field of nutritional glycobiology since 1996, and we will continue to be a leader in the future.”

Mannatech currently holds more than 45 patents in 30 countries for the technology related to Ambrotose complex.

In addition, many of Mannatech’s products are based on Real Food TechnologySM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients at nutritionally effective levels. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body. Mannatech offers the best alternative to synthetic vitamin and mineral products and so-called “super-juice” products.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at

About Mannatech
Mannatech, Incorporated develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, please visit

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into newinternational markets. Although Mannatech believes that the expectations, statements, and assumptions
reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

1 Mannatech, Incorporated donated the Ambrotose complex and placebo.

2 Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Developmental Neuropsychology 2010; 35(1): 66 -80.